Personalized Mesothelioma Treatments: Knockout Technology May Lead Researchers to
Personalized Mesothelioma Treatments: Knockout Technology May Lead Researchers .
Sigma Life Sciences, a biotechnology company that offers products for all disciplines of life science research from antibodies to animal models, has announced that they have added new genetically modified cancer cells to their range of high-quality cell lines. They expect that their human knockout and knock-in oncology cell lines will “offer researchers cellular models of cancer that are expected to enhance development of drugs for personalized medicine.” Just as with many cancers, mesothelioma treatments can differ dramatically across patients and personalized treatment targeted to a particular patient optimizes the potential for success of the treatment.
Mesothelioma is a rare, incurable cancer of the lining of the lungs or abdomen that is highly aggressive and is resistant to standard cancer treatments, making it a difficult disease to treat effectively. As a result, the disease has challenged the medical and research community for years. Although researchers have made progress in recent years, identifying an effective treatment modality for each patient combating the fatal disease remains elusive.
Using their proprietary tool CompoZr ZFN, Sigma believes their new cell lines will accelerate the development of personalized medicine for researchers through “target validation, identification of mechanistic actions of drugs and investigation of disease development, progression and remission.” The CompoZr tool allows Sigma to develop knockout and knock-in models that enable scientists in the development of personalized drugs.
Knockout is a genetic technique in which one of an organism’s genes is made inoperative, or knocked out, of the organism. The genes are then used to draw inferences from the difference between the knockout organism and normal individuals. Researchers focusing on mesothelioma treatments will especially benefit from this tool and development of cell lines as they continue their pursuit of an effective detection method, treatment, or cure for mesothelioma.
Sigma, which has received a silver medal as a “Top Ten Innovations of 2010″ from The Scientist magazine for developing knockout rats using CompoZr, will start its offering with cell lines that model colorectal and lung cancer. Dr. Edward Weinstein, director of SAGE Labs, Sigma’s genetic engineering laboratories focused on designing and producing off-the-shelf and custom animal models, said the use of knockout technologies will “provide scientists with powerful new tools to study human diseases.”
Source: http://blog.mesotheliomahelp.net/2011/02/knockout-technology-may-lead-researchers-to-personalized-mesothelioma-treatments.asp
Sigma Life Sciences, a biotechnology company that offers products for all disciplines of life science research from antibodies to animal models, has announced that they have added new genetically modified cancer cells to their range of high-quality cell lines. They expect that their human knockout and knock-in oncology cell lines will “offer researchers cellular models of cancer that are expected to enhance development of drugs for personalized medicine.” Just as with many cancers, mesothelioma treatments can differ dramatically across patients and personalized treatment targeted to a particular patient optimizes the potential for success of the treatment.
Mesothelioma is a rare, incurable cancer of the lining of the lungs or abdomen that is highly aggressive and is resistant to standard cancer treatments, making it a difficult disease to treat effectively. As a result, the disease has challenged the medical and research community for years. Although researchers have made progress in recent years, identifying an effective treatment modality for each patient combating the fatal disease remains elusive.
Using their proprietary tool CompoZr ZFN, Sigma believes their new cell lines will accelerate the development of personalized medicine for researchers through “target validation, identification of mechanistic actions of drugs and investigation of disease development, progression and remission.” The CompoZr tool allows Sigma to develop knockout and knock-in models that enable scientists in the development of personalized drugs.
Knockout is a genetic technique in which one of an organism’s genes is made inoperative, or knocked out, of the organism. The genes are then used to draw inferences from the difference between the knockout organism and normal individuals. Researchers focusing on mesothelioma treatments will especially benefit from this tool and development of cell lines as they continue their pursuit of an effective detection method, treatment, or cure for mesothelioma.
Sigma, which has received a silver medal as a “Top Ten Innovations of 2010″ from The Scientist magazine for developing knockout rats using CompoZr, will start its offering with cell lines that model colorectal and lung cancer. Dr. Edward Weinstein, director of SAGE Labs, Sigma’s genetic engineering laboratories focused on designing and producing off-the-shelf and custom animal models, said the use of knockout technologies will “provide scientists with powerful new tools to study human diseases.”
Source: http://blog.mesotheliomahelp.net/2011/02/knockout-technology-may-lead-researchers-to-personalized-mesothelioma-treatments.asp
Best Place of the World: You Must See
These are the best place of the world you must see. you can see here natural beauty such as Himalaya.
This spectacle of awesome dimensions …the 3000 kilometer long towering mountain range with tiers of rock, ranges upon ranges, sky scraping peaks and canyons, is the planet’s highest mountain system and includes the world’s highest peaks; Mount Everest and K2. It stretches through Afghanistan, Bhutan, China, India, Nepal and Pakistan. This is where earth meets the sky!
Read more: More of Most Beautiful Places Of The World http://www.unp.co.in/f143/more-of-most-beautiful-places-of-the-world-54305/#ixzz1FEPgqiCH
Mount Kilimanjaro – Africa
Ernest Hemingway described this mountain as, “as wide as all the world, great, high and unbelievably white,” in his book, “The Snows of Kilimanjaro.”
Read more: More of Most Beautiful Places Of The World http://www.unp.co.in/f143/more-of-most-beautiful-places-of-the-world-54305/#ixzz1FEPlFJH4
This spectacle of awesome dimensions …the 3000 kilometer long towering mountain range with tiers of rock, ranges upon ranges, sky scraping peaks and canyons, is the planet’s highest mountain system and includes the world’s highest peaks; Mount Everest and K2. It stretches through Afghanistan, Bhutan, China, India, Nepal and Pakistan. This is where earth meets the sky!
Read more: More of Most Beautiful Places Of The World http://www.unp.co.in/f143/more-of-most-beautiful-places-of-the-world-54305/#ixzz1FEPgqiCH
Mount Kilimanjaro – Africa
Ernest Hemingway described this mountain as, “as wide as all the world, great, high and unbelievably white,” in his book, “The Snows of Kilimanjaro.”
Read more: More of Most Beautiful Places Of The World http://www.unp.co.in/f143/more-of-most-beautiful-places-of-the-world-54305/#ixzz1FEPlFJH4
Niagara Falls-----
What is Cancer
Cancer has become a dreadful word in most people's mind. There is no scarier diagnosis than that of cancer. Cancer is indeed a serious, life-threatening illness, with an estimated 500, 000 deaths each year.
Cancer Pictures aims to clarify some of the questions you have.
Cancer is a kind of disease where certain cells of the body undergo an out-of-control, abnormal cell growth. Our body is composed of millions of cells, which coordinate in groups, forming body tissues and organs. These cells grow and reproduce constantly, replacing defective or dying cells. In cancer, however, cellular division and reproduction goes uncontrolled and uncoordinated. In some studies, this undesirable process by cancer cells is known to have been caused by a damage or defect in the cell's DNA, the genetic material that defines cellular characteristics and function.
Cancer cells division is much different from normal cells. Normal cells reproduce themselves exactly how they are and stop when they mature at the right time and specialize according to their specific function. Normal cells stick together in the right place and when they are damaged, they self-destruct as new cells begin to proliferate to destroy them. Cancer cell division is a different story. Cancer cells do not stop reproducing, they go on and on without stopping, forming clumps and affecting normal body function. They do not heed and obey any signals from other cells and they do not stick together. They do not specialize and thus they stay immature.
Cancer begins to harm the body when cancer cells reproduce and clump together to form what is called a tumor. The tumor presses, crushes and destroys what is around it, including non-cancerous cells and tissues. This is what defines the many symptoms cancer patients often experience. As the tumor grows, it interferes with the nervous, digestive and circulatory systems, altering normal body functions. A tumor that stays in one part of the body, and which demonstrate limited growth is called benign. Benign cancer is usually non-threatening. However, when cancer cells manage to move and migrate throughout the body, they are called malignant cells. Malignant cancer is more dangerous, as it migrates and invades other body organs. This process, called metastasis, leads to serious conditions which maybe difficult to treat.
Cancer diagnosis is critical in the treatment of cancer. Early detection increases the odds of treatment and survival of patient with cancer. Cancer diagnosis is based on a person's symptoms and the results of his physical examination. Screening tests are also performed which will define what type of cancer he has. Imaging techniques such as CT scans, X-rays, PET scans and ultrasound helps detect where the cancer cells specifically. Biopsy, the process of extracting cancer cells and examining them under a microscope, is the absolute and most reliable way to diagnose cancer. Altogether, molecular diagnostics, imaging techniques and biopsies are used to diagnose the presence of cancer.
After diagnosis, how far the cancer has spread throughout the body has to be determined. This process is called staging. The most common staging method is called the TNM system, where T (which is scored from 1-4) suggests the size and the extent of the primary tumor, N (0-3) indicates the degree of spread to nearby lymph nodes and M (0-1) suggests the degree to which the cancer has metastasized to other parts of the body. Another simpler categorization of cancer is staging from 0-4. Stage 1 tumors are generally curable while Stage 4 indicates a more grave condition, which is that the tumor is inoperable or that cancer has spread and is untreatable.
The National Cancer Institute has listed the most common cancer types based on cancer diagnosis that has the greatest frequency. To qualify as a common cancer, the estimated annual incidence has to be 35,000 cases or more. The most common types of cancer are skin cancer, breast cancer, lung cancer, prostate cancer and colon cancer. Each of these is discussed further in the next pages of cancer pictures.
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